Toronto has seven home runs in the first two games of the series and a major league-leading 81 since June 16.
Baltimore starter Asher Wojciechowski (2-4) had given the Orioles two great starts in his previous two outings but didn't have it this time.
Vladimir Guerrero Jr. also drove in a run on Friday and has 17 RBIs in his last six games.
Despite being strapped for pitchers, the Blue Jays have limited Baltimore to a pair of runs in each of the last two games.
Marcus Stroman may have left the Toronto Blue Jays unceremoniously, resulting in an impromptu exit interview in the clubhouse that made headlines, but Aaron Sanchez waxed poetic about his tenure after being traded to the Houston Astros on Wednesday. Derek Fisher recorded his first RBI as a Jay, bringing home Galvis with a single in the ninth ... His ninth-inning single expanded Toronto's lead to 5-2. This year, he's 1-0 with a 1.35 ERA vs the Blue Jays.
Earlier, the Blue Jays placed left-hander Ryan Borucki on the 10-day injured list with left elbow inflammation, retroactive to Sunday.
"Even though we lost all the pitching, the guys that are still back there are doing well", manager Charlie Montoyo said. The miscue, on which Fisher was charged with an error, came two nights after Fisher made his Jays debut when he finished an at-bat for Randal Grichuk, who fouled a pitch off his own mouth. "I really did work hard in the off-season and trusted myself, and I really believed that this was going to happen this year", Diaz said through team interpreter Hector Lebron of making it up to the Jays.
Sanchez, a homegrown Blue Jay, has been with the team since 2014 and was once considered one of the team's building blocks for the future.
The Jays tied the game 4-4 in the seventh on a two-run home run by Reese McGuire and figured they had taken a lead two batters later. Rondon was acquired from the White Sox a few days ago but did not play Friday night. "And it makes for a much different calculus when you're talking about trading those guys than when you're looking at a situation we had with Andrew Cashner, who was not going to be here next year". Jansen got his three-run homer and Guerrero added his run-scoring double to give the Jays an 8-1 lead. "Got out of a big jam in third inning and that was big momentum for me". "It's worked out well for us". The right-hander allowed four runs on six hits - including two homers - in 4 2/3 innings. Galvis went deep with two out in the third off Orioles starter Dylan Bundy.
Baltimore scored a run on a Jonathan Villar groundout in the fifth before Toronto broke it open with four runs off Jimmy Yacabonis in the sixth.